Optimized Folate

Supports Neurotransmitter Synthesis and Critical Enzyme Reactions

Folate is involved in neurotransmitter synthesis and critical enzymatic reactions throughout the body. By depleting excess homocysteine, folate benefits cardiovascular health and nervous system function.

A Bioactive Form of Folate

Those who take ordinary folate supplements, however, may not be experiencing its full spectrum of effects. This is because once ingested, not everyone converts folate to its biologically active form called 5-methyltetrahydrofolate (5-MTHF).¹

Research shows that in a large proportion of the population, genetic enzyme deficiencies inhibit the conversion of folate to 5-MTHF, leaving many vulnerable to low blood folate levels (and higher-than-desired homocysteine).

A more useful approach is to take the bioactive folate 5-MTHF directly, which has been declassified as a drug and is now available as a dietary supplement. 5-MTHF has been shown to dramatically raise red blood cell folate levels² compared with folic acid supplementation.

This bioactive folate is up to seven times more bioavailable than folic acid. This greater bioavailability is especially important in people who have a genetic enzyme deficiency³ since it requires no conversion to become metabolically active.

Maintaining Healthy Homocysteine Levels

People with elevated homocysteine levels have a greater risk of cognitive decline.⁴ Unlike folic acid, 5-MTHF is able to cross the blood-brain barrier, which is especially important for people with cognitive difficulties, to enhance the synthesis of acetylcholine in the brain — the neurotransmitter associated with memory.

Co-Supplement with B12 for Enhanced Effect

Studies also show that the effectiveness of 5-MTHF can be further enhanced by co-supplementing with methylcobalamin (the active form of vitamin B12),⁵ vitamin B6, and riboflavin.⁶ Support your cardiovascular health and more with Optimized Folate